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Title: Serum Choline is Associated with Cognitive and Motor Development in International Adoptees

Study Location: N/A

Type of Paper: Abstract

Purpose: To explore the relationship between choline and brain development in international adoptees

Measures: Serum choline; Bayley Scales of Infant Development III (mental and motor development); height-for-age

Participants: 21 international adoptees from Eastern Europe, Ethiopia and China between the ages of 8 and 18 months at arrival into the US.

Methods: Statistical analyses were conducted to predict Bayley scores with three risk factors: choline, age at adoption and height-for-age.

Results: Choline was not related to age or height-for-age at adoption. Choline was the only significant predictor for the Bayley mental and motor scale. The association between choline and motor development was nonlinear.

Conclusions and Implications: Choline status at adoption is a better predictor of mental and motor development than age or height-for-age. The nonlinear relationship between choline and motor development suggests a threshold effect for choline. The association may be due to the many roles choline plays in neurodevelopment, including brain myelin and gene regulation. On the other hand, choline status may simply be a marker for general malnutrition or an indicator of the severely deprived environment prior to adoption.

Citation/Reference: Fuglestad, A.J., Innis, S., Johnson, D.E., Kroupina, M.G., Georgieff, M.K. Serum Choline is Associated with Cognitive and Motor Development in International Adoptees. Abstract. 2013.


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